The Della Rovere Chapel in the basilica of Santa Maria del Popolo in the city center of Rome, Italy. The Della Rovere or Nativity Chapel is the first side chapel on the right aisle. It was furnished by Cardinal Domenico della Rovere from 1477 after the reconstruction of the church by his relative, Pope Sixtus IV. The pictorial decoration is attributed to Pinturicchio and his school. The main altar-piece, The Adoration of the Child with St Jerome is an exquisite autograph work by Pinturicchio himself. The tomb of Cardinal Cristoforo della Rovere died in 1478, a work by Andrea Bregno and Mino da Fiesole, was erected by his brother. On the right side the funeral monument of Giovanni de Castro died 1506 is attributed to Francesco da Sangallo. The chapel is one of the best preserved monuments of quattrocento art in Rome. Santa Maria del Popolo was reconstructed between 1472 and 1477 on the orders of Pope Sixtus IV. The church is hemmed in between the Pincian Hill and Porta del Popolo, one of the gates in the Aurelian Wall as well as the starting point of Via Flaminia, the most important route from the north. Its location made the basilica the first church for the majority of travelers entering the city. The church contains works by several famous artists, such Raphael, Gian Lorenzo Bernini, Caravaggio, Alessandro Algardi, Pinturicchio, Andrea Bregno, Guillaume de Marcillat and Donato Bramante.

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